Extracellular Glucoamylase from the Isolate Aspergillus fumigatus

Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus.

Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of...

A sticky situation: extracellular DNA shapes Aspergillus fumigatus biofilms

Multicellular stages play an important role for microbial communities as well as during infections. For one of the major fungal pathogens, the environmental mold Aspergillus fumigatus, an interesting and relevant morphotype beyond the conidial and hyphal stages has gained increasing attention: the multicellular biofilm. Such hyphal communities were first described for A. fumigatus in 2007 (Mowa...

Evidence of multiple extracellular phospholipase activities of Aspergillus fumigatus.

Extracellular phospholipase activity has been implicated in the pathogenesis of several bacterial infections. Recently, extracellular phospholipase activity has been proposed as a virulence factor in the opportunistic yeast Candida albicans. Aspergillus fumigatus is the most pathogenic member of its genus, responsible for > 90% of infections. Previously, no specific virulence factors have been ...

Structure of the catalytic domain of glucoamylase from Aspergillus niger.

Glucoamylase from Aspergillus niger is an industrially important biocatalyst that is utilized in the mass production of glucose from raw starch or soluble oligosaccharides. The G1 isoform consists of a catalytic domain and a starch-binding domain connected by a heavily glycosylated linker region. The amino-terminal catalytic domain of the G1 isoform generated by subtilisin cleavage has been cry...

Kinetic patterns of glucoamylase isozymes isolated from Aspergillus species.